MONDAY, May 2, 2022 (HealthDay News) — Child body size has a causal influence on the risk of type 1 diabetes (T1D), according to a study published online April 28 in Nature Communication.
Tom G. Richardson, Ph.D., of the University of Bristol in the UK, and his colleagues used Mendelian randomisation (MR) to prove that a child’s body size has an effect on the risk of T1D .
The researchers found that childhood body size had an effect on the risk of T1D (odds ratio, 2.05 per change in body size category), which persisted after multivariate MRI, including consideration body size at birth and in adulthood (odds ratio, 2.32) . Using data from a large-scale meta-analysis of T1D including 15,573 cases and 158,408 controls, the direct effect of child body size was validated (odds ratio, 1.94). Childhood body size has also been found to influence the risk of asthma, eczema and hypothyroidism, although these effects were mediated by body size later in life.
“Our findings underscore the importance of implementing preventive policies to reduce the prevalence of childhood obesity and its subsequent influence on the growing number of T1D cases,” the authors write. “This will help ease the healthcare burden and potentially improve the quality of life for people living with this lifelong condition.”
Two authors disclosed financial ties to the pharmaceutical industry.